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Anticoagulant Rodenticides & LD50

Anticoagulant Rodenticides

Anticoagulants work by preventing the assimilation of vitamin K1, one of 12 ‘blood clotting factors’ within vertebrates. Once a lethal dose of poison has been eaten by the rodent, there is a lag period while the existing vitamin K1 in the body is used up. This normally takes three to four days, after which the blood will no longer be able to clot, and any haemorrhaging inside the body will lead to death. The great advantage of the lag period is that rodents never associate the bait they have eaten, with the symptoms of poisoning they go through. This means it is possible to attain 100% control of the population, as the rats will continue to feed on the bait ignorant of the fact it is killing them.

‘Acute’ poisons which work more quickly (within minutes of being eaten), have several disadvantages over anticoagulants.  Firstly, if a sub-lethal dose is consumed, rats and mice may become ill but not die. Such illness is remembered and the rats will avoid eating the bait again - compromising the control programme. Typically only 55-65% of the population will be killed when acute poisons are used. A significant advantage of anticoagulants is safety. In cases of accidental poisoning of non-target species such as cats, dogs and children, the lag period allows these baits to be effectively anti-doted.

Active ingredients The most widely used anticoagulant active ingredients used in the UK as rodenticides are:

  • Difenacoum
  • Bromadiolone
  • Brodifacoum

Each active ingredient has a different level of toxicity to mice, rats and non-target animals such as birds and dogs.

First Generation

Second Generation
Acute Rodenticides

Whole Wheat Rodenticides

Whole Wheat Baits

Highly palatable and effective against most pest rodents, particularly where the population has been feeding on whole grain foodstuffs. While mice peel off the outer shell of a grain, rats will pick up a grain in its paws and eat it in three or four bites. They are made from micronised grain, which has been treated to prevent germination and start the conversion of starches to sugars, making it even more attractive to rodents.

Block Baits

Formulated using edible waxes which bind the ingredients together, including high quality culinary grade wheat flour and chopped wheat. Block baits are made with a hole in the centre so they can be wired into place or threaded onto a spindle inside a bait station. This offers complete bait security from non-target animals.
Pasta Bait

Pasta Bait

Sometimes referred to as ‘paste’ bait or ’fresh bait'. It is made from a mixture of wheat flour, chopped grain, soft lard and synthetic peanut flavouring and offers a high calorie, highly palatable feed which is ideal for most situations. It is particularly useful where rodents are being slow to take other types of bait, or where it is proving difficult to tempt them away from their current food source. Pasta baits are available in mastic tubes or in 15g ‘T’ bags.

Other Actives in Rodent Droppings

Other Ingredients

Baits have been designed to ensure rats and mice find them, eat some, then return later to eat some more. Special aromas help rodents locate them easily and synthetic taste additives encourage repeated feeding. Biological preservatives stop the growth of fungi or bacteria when used in damp conditions. Strong dyes are included which colour the rats’ droppings, giving a good indication as to whether they are eating the bait.

Non-Target Toxicity - LD50 Grams of Bait Per Kilo of Animal

  50ppm Bromadiolone Baits 50ppm Difenacoum Baits 50ppm Brodifacoum Baits 50ppm Flocoumefen Baits 250ppm Warfarin Baits
Rabbit 20.0 40.0 5.8 14.0 3200.0
Pig 60.0 1600.0 10.0 - 4.0
Dog 200.0 1000.0 5.0 1.5 80.0
Cat 500.0 2000.0 500.0 - 40.0
Chicken 1000.0 1000.0 200.0 4000.0
Sheep 2000.0 60.0 -


Anticoagulant Rodent toxicity

Anticoagulant (active ingredient) Difenacoum Bromadiolone Brodifacoum
Dosing Multi-feed Multi-feed Single-feed
Lethal Dose - Rat 9.0g 5.6g 1.3g
Lethal Dose - Mouse 0.4g 0.9g 0.2g